Mark’s research focuses on epidemiological and economic modelling of vaccines to support evidence-based public health decision making. He has published work covering a range of antigens for current and pipeline vaccines including measles, HPV, pneumococcus, rotavirus, influenza, dengue, EV71 and RSV, as well as methodological papers advancing the ways vaccines are evaluated.
- Jit, M., Hutubessy, R., Png, M.E., Sundaram, N., Audimulam, J., Salim, S. and Yoong, J., 2015. The broader economic impact of vaccination: reviewing and appraising the strength of evidence. BMC medicine, 13(1), p.209.
- Jit, M., Brisson, M., Portnoy, A. and Hutubessy, R., 2014. Cost-effectiveness of female human papillomavirus vaccination in 179 countries: a PRIME modelling study. The Lancet Global health, 2(7), pp.e406-e414.
- Jit, M. and Brisson, M., 2011. Modelling the epidemiology of infectious diseases for decision analysis. Pharmacoeconomics, 29(5), pp.371-386.
I am a mathematical modeller have worked at LSHTM as an Assistant Professor of Infectious Disease Modelling since 2014. My work focuses on using vaccines to controlling antibiotic resistance and understanding the determinants of HIV acquisition.
My focus is on severe outcomes following respiratory virus infections. I also work on vaccination strategies for Ebola virus disease.
As a part of Vaccine Impact Modelling Consortium, I mainly focus on estimating the impact of measles and rotavirus vaccines. In addition, I look at the effects of changing demography and seasonality on the dynamics of these two infectious diseases, and how better to control them.
- Klepac, P., Kissler, S. and Gog, J., 2018. Contagion! The BBC Four Pandemic–The model behind the documentary. Epidemics.
- Klepac, P., Megiddo, I., Grenfell, B.T. and Laxminarayan, R., 2016. Self-enforcing regional vaccination agreements. Journal of The Royal Society Interface, 13(114), p.20150907.
- Klepac, P., Funk, S., Hollingsworth, T.D., Metcalf, C.J.E. and Hampson, K., 2015. Six challenges in the eradication of infectious diseases. Epidemics, 10, pp.97-101.
- Klepac, P., Metcalf, C.J.E., McLean, A.R. and Hampson, K., 2013. Towards the endgame and beyond: complexities and challenges for the elimination of infectious diseases.
- Klepac, P., Laxminarayan, R. and Grenfell, B.T., 2011. Synthesizing epidemiological and economic optima for control of immunizing infections. Proceedings of the National Academy of Sciences, 108(34), pp.14366-14370.
- Klepac, P. and Caswell, H., 2011. The stage-structured epidemic: linking disease and demography with a multi-state matrix approach model. Theoretical Ecology, 4(3), pp.301-319.
My research focus is epidemiological and economic modelling of infectious diseases at the interface of infectious disease system dynamics and public health systems research. The research goal is to generate valuable findings that can assist policy makers locally and globally in choosing optimal public health interventions, including optimal vaccine program investments to reduce infectious disease burden effectively, efficiently and equitably.
- Dorratoltaj, N., Marathe, A., Lewis, B.L., Swarup, S., Eubank, S.G. and Abbas, K.M., 2017. Epidemiological and economic impact of pandemic influenza in Chicago: Priorities for vaccine interventions. PLoS computational biology, 13(6), p.e1005521.
- Kang, G.J., Ewing-Nelson, S.R., Mackey, L., Schlitt, J.T., Marathe, A., Abbas, K.M. and Swarup, S., 2017. Semantic network analysis of vaccine sentiment in online social media. Vaccine, 35(29), pp.3621-3638.
- Kang, G.J., Culp, R.K. and Abbas, K.M., 2017. Facilitators and barriers of parental attitudes and beliefs toward school-located influenza vaccination in the United States: Systematic review. Vaccine, 35(16), pp.1987-1995.
Mathematical modelling, vaccines, pneumococci
I am an Assistant Professor in Epidemiology in the Faculty of Epidemiology and Public Health (Department of Infectious Disease Epidemiology), London School of Hygiene and Tropical Medicine.
I am involved in the planning of cohort re-enrolment for long term outcomes of Group B Streptococcus (GBS) disease in infancy, specifically neurodevelopmental impairment, as well as other health and socio-economic consequences. Currently I am also investigating statistical methods for data pooling. Such work will contribute to the development of a value proposition for GBS maternal immunization with WHO.
More broadly I am using statistical modelling to inform public health decisions about vaccination and other control measures for infectious diseases.